Murine C-type RNA Virus from Spontaneous Neoplasms: in vitro Host Range and Oncogenic Potential

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Science  17 Aug 1973:
Vol. 181, Issue 4100, pp. 665-667
DOI: 10.1126/science.181.4100.665


Strain BALB/c mice harbor at least two host range variants of marine leukemia virus. One variant, which is host-cell tropic, is the predominant isolate from neoplastic tissues and produced lymphoreticular neoplasms when injected into BALB/c newborn mice. A second variant, whicht is isolated throughout life, grows poorly in host embryonic cells in culture and was not associated with lymphoreticular neoplasm induction when injected into newborn BALB/c mice.