12,13-Epoxy-Δ9-Trichothecenes as the Probable Mycotoxins Responsible for Stachybotryotoxicosis

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Science  24 Aug 1973:
Vol. 181, Issue 4101, pp. 758-760
DOI: 10.1126/science.181.4101.758


Stachybotrys atra cultures grown on oats produced five compounds toxic to brine shrimp; three are the sesquiterpenoid mycotoxins known as 12,13-epoxy-Δ9-trichothecenes. One trichothecene is roridin E, a known metabolite of Myrothecium verrucaria. The other two were hydrolyzed to verrucarol, the product of roridin and verrucarin hydrolysis. Spectroscopic data indicate that the two remaining compounds are also 12,13-epoxy-Δ9-trichothecenes. These metabolites are probably among those responsible for stachybotryotoxicosis.