MHPG Excretion in Depressive Disorders: Relation to Clinical Subtypes and Desynchronized Sleep

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Science  24 Aug 1973:
Vol. 181, Issue 4101, pp. 762-764
DOI: 10.1126/science.181.4101.762


The urinary excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) was significantly lower in patients with manic-depressive depressions than in patients with chronic characterological depressions. There was an inverse relationship between MHPG excretion and the amount of time spent in desynchronized sleep, particularly in the manic-depressive disorders. Excretion of MHPG was not related to the degree of retardation, agitation, or anxiety in these patients.