Human Chorionic Gonadotropin: Its Possible Role in Maternal Lymphocyte Suppression

Science  31 Aug 1973:
Vol. 181, Issue 4102, pp. 845-847
DOI: 10.1126/science.181.4102.845


Human chorionic gonadotropin completely inhibits the response of lymphocytes to phytohemagglutinin. The effect is both reversible and noncytotoxic. These observations support the theory that the fetus is accepted because human chorionic gonadotropin represents trophoblastic surface antigen and blocks the action of maternal lymphocytes.