Peroxidase Mediated Antimicrobial Activities of Alveolar Macrophage Granules

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Science  31 Aug 1973:
Vol. 181, Issue 4102, pp. 849-850
DOI: 10.1126/science.181.4102.849


The 20,000g pellet obtained by centrifugation of a homogenate of rabbit alveolar macrophages has antibacterial activity in the presence of a hydrogen peroxide-generating system and iodide. Peroxidase activity has been demonstrated in this fraction. Addition of 3-amino-1,2,4-triazole diminished the antibacterial activity of the pellet-hydrogen peroxide-iodide system.