Reports

Infusion of 2-Deoxy-D-Glucose into the Hepatic-Portal System Causes Eating: Evidence for Peripheral Glucoreceptors

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Science  31 Aug 1973:
Vol. 181, Issue 4102, pp. 858-860
DOI: 10.1126/science.181.4102.858

Abstract

Injections of 2-deoxyglucose into the hepatic-portal system of normal rabbits increased eating to a greater extent and with shorter latency than comparable injections of 2-deoxyglucose into the jugular vein or into the hepaticportal circulation of the vagotomized rabbit. These differences suggest the existence of vagally mediated peripheral glucoreceptors important in the initiation of food intake.

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