Zinc: A Trace Element Essential in Vitamin A Metabolism

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Science  07 Sep 1973:
Vol. 181, Issue 4103, pp. 954-955
DOI: 10.1126/science.181.4103.954


Zinc is necessary to maintain normal concentrations of vitamin A in plasma. By using animals deficient in both zinc and vitamin A, it was demonstrated that zinc is necessary for normal mobilization of vitamin A from the liver. These results suggest that cases of depressed vitamin A in plasma, unresponsive to vitamin A therapy, may respond to zinc supplementation.