Breast Cancer: Induction of Differentiation by Embryonic Tissue

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Science  14 Sep 1973:
Vol. 181, Issue 4104, pp. 1057-1058
DOI: 10.1126/science.181.4104.1057


A mouse mammary tumor, adenocarcinoma BW 10232, was maintained in vitro for 14 days, separated from embryonic mammary mesenchyme by a Millipore filter. Tubules developed in the tumor; deoxyibonucleic acid synthisis declined; and a presumptive acid mucopolysaccharide matrix, not evident in the controls, appeared.