Cytomegalovirus: Conversion of Nonpermissive Cells to a Permissive State for Virus Replication

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Science  14 Sep 1973:
Vol. 181, Issue 4104, pp. 1060-1061
DOI: 10.1126/science.181.4104.1060


Human embryonic kidney cells are epithelioid cells which are normally nonpermissive for in vitro replication of human cytomegalovirus. These cells were converted to a permissive state for the virus by prior treatment with 5-iodo-2'-deoxyuridine. When this method was used, a nonpermissive cell was made permissive to an infecting virus.