Spontaneous Whole Brain Slow Potential Changes during Recovery from Experimental Neurosurgery

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Science  21 Sep 1973:
Vol. 181, Issue 4105, pp. 1176-1178
DOI: 10.1126/science.181.4105.1176


Prolonged, nonlocalized brain slow potential changes, frequently associated with cortical spreading depression, occur spontaneously during 5 days following brain implant surgery in rats. These potentials are accompanied by reductions in multiple nerve cell activity and reductions in behavioral motility. The method used in this study provides a tool for evaluating recovery from neurosurgical trauma or other brain injuries, and for testing procedures that facilitate or impede this process.