Human Embryonic Kidneys in Organ Culture: Abnormalities of Development Induced by Decreased Potassium

See allHide authors and affiliations

Science  21 Sep 1973:
Vol. 181, Issue 4105, pp. 1178-1179
DOI: 10.1126/science.181.4105.1178


Human embryonic kidneys of 5 to 12 weeks of gestation were grown in organ culture. Potassium concentrations of 3 to 6 milliequivalents per liter produced decreased ureteral bud branching, failure of nephron induction, and occasional cystic dilatations of the ureteral bud. Normal development of the kidney occurred at potassium concentrations of 6.5 to 10 milliequivalents per liter. These studies confirm the importance of relative stability of the potassiunm concentration in the development of the embryonic kidney.