Recombinant Inbred Lines: Value in the Genetic Analysis of Biochemical Variants

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Science  28 Sep 1973:
Vol. 181, Issue 4106, pp. 1249-1252
DOI: 10.1126/science.181.4106.1249


Analysis of inducibility by androgens and electrophoretic mobility of kidney glucuronidase in progenitor and derived recombinant inbred mouse lines suggests that a single major regulatory gene at or near the glucuronidase structural gene on chromosome 5 determines the rate of enzyme accumulation.