Methyltetrahydrofolic Acid Mediates N- and O-Methylation of Biogenic Amines

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Science  05 Oct 1973:
Vol. 182, Issue 4107, pp. 74-75
DOI: 10.1126/science.182.4107.74


A variety of mammalian and avian tissues N- and O-methylate indoleamines and phenylethylamines, with methyltetrahydrofolic acid as the methyl donor. Because it is considerably more efficient than S-adenosylmethionine, methyltetrahydrofolic acid may be the natural methyl donor in this reaction. With methyltetrahydrofolic acid, serotonin is O-methylated to 5-methoxytryptamine, a novel indoleamine in mammalian brain.