Nerve Growth Factor: Relationship to the Cyclic AMP System of Sensory Ganglia

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Science  05 Oct 1973:
Vol. 182, Issue 4107, pp. 79-81
DOI: 10.1126/science.182.4107.79


Nerve growth factor and N6,O2' dibutyryl adenosine 3',5'-monophosphate both stimulate neurite elongation by explanted ganglia. However, the addition of nerve growth factor does not lead to increased amounts of adenosine 3',5'-monophosphate in intact ganglia, nor does it stimulate adenylate cyclase activity in broken ganglia cells.