Complete Amino Acid Sequence of the Mu Heavy Chain of a Human IgM Immunoglobulin

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Science  19 Oct 1973:
Vol. 182, Issue 4109, pp. 287-291
DOI: 10.1126/science.182.4109.287


The amino acid sequence of the µ, chain of a human IgM immunoglobulin, including the location of all disulfide bridges and oligosaccharides, has been determined. The homology of the constant regions of immunoglobulin µ, γ, α, and ε heavy chains reveals evolutionary relationships and suggests that two genes code for each heavy chain.