Phosphorylation of Muscle Membranes: Identification of a Membrane-Bound Protein Kinase

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Science  30 Nov 1973:
Vol. 182, Issue 4115, pp. 927-929
DOI: 10.1126/science.182.4115.927


A membrane-bound protein kinase occurs in membranes derived from rat skeletal muscle and appears limited to a surface membrane fraction. The enzyme is magnesium dependent, is only minimally stimulated by cyclic nucleotides, and phosphorylates serine and to a lesser extent threonine residues of three membrane proteins with molecular weights of less than 30,000.