Ontogeny and Peripheralization of Thyimic Lymphocytes

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Science  30 Nov 1973:
Vol. 182, Issue 4115, pp. 931-933
DOI: 10.1126/science.182.4115.931


Reciprocal transplantation of undifferentiated thymic primordia between diploid and triploid chromosomally marked frog embryos has revealed that thymic lymphocytes are ontogenically derived from elements of the thymic primordium rather than from blood-borne stem cells that migrated into the developing organ. Virtually all the lymphocytes in the spleen, kidneys, and bone marrow of adult frogs are descendants of these original thymic stem lymphocytes.