Mammary Carcinoma: Enzymatic Block in Disialoganglioside Biosynthesis

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Science  30 Nov 1973:
Vol. 182, Issue 4115, pp. 935-937
DOI: 10.1126/science.182.4115.935


The sialyl transferase of disialoganglioside formation is depressed in mammary tumors induced in the rat by 7,12-dimethylbenz[a]anthracene. Specific activities of other glycosyltransferases of the pathway ceramide to monosialo-ganglioside are unchanged or elevated so that the ganglioside GM1 accumulates and higher gangliosides are depressed. These findings with a solid tumor are critical to an involvement of gangliosides in the cell-surface changes of tumorigenesis.