Direct Evidence for a Colchicine-Induced Impairment in the Mobility of Membrane Components

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Science  14 Dec 1973:
Vol. 182, Issue 4117, pp. 1136-1138
DOI: 10.1126/science.182.4117.1136


Freeze-etch electron microscopy was used to show that colchicine interacts with membranes of the ciliate protozoan Tetrahymena pyriformis. Colchicine impairs the temperature-induced translational and vertical mobility of the membrane-intercalating particles of the freeze-fractured alveolar membranes lying just below the plasma membranes.