Acute Lymphoblastic Leukemic Cells with T (Thymus-Derived) Lymphocyte Markers

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Science  28 Dec 1973:
Vol. 182, Issue 4119, pp. 1355-1356
DOI: 10.1126/science.182.4119.1355


Five of nine children with acute lymphoblastic leukemia had lymphoblasts that bound sheep erythrocytes or reacted with antiserum to thymocytes, suggesting involvement of T (thymus-derived) cells. When lymphoblasts from all patients were examined by immunofluorescence they were found to lack a marker for B (bone marrow or bursa-equivalent) cells, that is, the presence of surface immunoglobulins.