In vivo Inhibition of Growth of Two Hormone-Dependent Mammary Tumors by Dibutyryl Cyclic AMP

Science  11 Jan 1974:
Vol. 183, Issue 4120, pp. 87-88
DOI: 10.1126/science.183.4120.87


Growth of hormone-dependent rat mammary tumors was arrested in vivo by N6,O2'-dibutyryl cyclic adenosine 3',5'-monophosphate. Estrogen concentration did not change, but acid ribonuclease activity and synthesis increased during treatment with the dibutyryl cyclic nucleotide, as was shown during tumor regression due to hormonal deprivation. Growth arrest, thus, appears to derive from enhanced tissue catabolism.