Reports

An Enzymatic Mechanism for the Antithrombotic and Antihemostatic Actions of Aspirin

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Science  25 Jan 1974:
Vol. 183, Issue 4122, pp. 325-327
DOI: 10.1126/science.183.4122.325

Abstract

Aspirin-type drugs may inhibit irreversible clumping of human blood platelets by blocking the enzymatic conversion of arachidonic acid to a hitherto undiscovered factor, labile aggregation-stimulating substance, which triggers aggregation and to prostaglandin E2, which sensitizes the platelets to its aggregatory effects.