Acetylenic Analog of Arachidonate That Acts Like Asprinn on Platelets

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Science  25 Jan 1974:
Vol. 183, Issue 4122, pp. 327-330
DOI: 10.1126/science.183.4122.327


Development of irreversible platelet aggregation and the accompanying release of platelet-bound serotonin and production of prostaglandins is suppressed by 5,8,11,14-eicosatetraynoic acid (TYA). These findings may be explained by an ability of TYA to inhibit the enzymatic conversion of arachidonate to a newly recognized factor, labile aggregation-stimulating substance, which induces platelet aggregation, and to prostaglandins E2 and F.