Fecal Bacterial β-Glucuronidase: Control by Diet

Science  01 Feb 1974:
Vol. 183, Issue 4123, pp. 416-417
DOI: 10.1126/science.183.4123.416


The effect of a mixed Western, high meat diet or a nonmeat diet on the intestinal bacterial β-glucuronidase activity was studied in human volunteers. This enzyme was significantly higher in stools of subjects on a high meat diet as compared to the nonmeat regimen. Thus, intestinal flora of subjects on a high meat diet was more able to hydrolyze glucuronide conjugates than that of individuals on a nonmeat diet. This, in turn, may raise the amount of substances, such as carcinogens, within the colonic lumen.