Tracheobronchial Epithelial Multinucleation in Malignant Disease

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Science  08 Feb 1974:
Vol. 183, Issue 4124, pp. 525-526
DOI: 10.1126/science.183.4124.525


Multinucleated tracheobronchial ciliated epithelial cells seen in smears from 112 patients suffering from a wide variety of malignant tumors were found to be 2.08 times more numerous than in a control group comparable in sex, age (decades), and smoking habit but without prediagnosed malignancies. The recognition of this phenomenon may lead to the development of a new test for the diagnosis of occult cancer and may open new pathways for investigation of cancer-host relationships.