Biosynthesis of α-Ecdysone by Prothoracic Glands in vitro

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Science  08 Feb 1974:
Vol. 183, Issue 4124, pp. 529-530
DOI: 10.1126/science.183.4124.529


An in vitro study in which isolated prothoracic glands of the Bombyx silkworm were cultured has provided definite evidence that the prothoracic gland is the site where molting hormone is synthesized. The hormone behaved very similarly to free ecdysone on thin-layer chromatography. Analysis by liquid chromatography and mass fragmentography revealed that the hormone is identical with α-ecdysone.