Book Reviews

Adenosine 3',5'-Monophosphate: Inhibition of Complement-Mediated Cell Lysis

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Science  15 Feb 1974:
Vol. 183, Issue 4125, pp. 659-661
DOI: 10.1126/science.183.4125.659


An increase in adenosine 3',5'-monophosphate (cyclic AMP) in rat mast cells, achieved by stimulating the cells with prostaglandin E1, by preventing cyclic AMP breakdown with aminophylline, or by adding exogenous dibutyryl cyclic AMP, prevented complement-mediated cytolysis as assessed by both histamine release and vital dye exclusion. Dibutyryl cyclic AMP also suppressed water-induced osmotic lysis.