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Failure to Confirm Cyclic AMP as Second Messenger for Norepinephrine in Rat Cerebellum

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Science  15 Feb 1974:
Vol. 183, Issue 4125, pp. 663-664
DOI: 10.1126/science.183.4125.663


Microiontophoretic applications of adenosine 3',5'-monophosphate (cyclic AMP) to spontaneously active, electrophysiologically identified Purkinje cells of the rat cerebellum failed to mimic the strong depressant action of norepinephrine on the same cells. These findings, in combination with a reevaluation of other studies, cast doubt on the hypothesis that cyclic AMP mediates the depressant actions of norepinephrine in the cerebellum.