Partial Purification of an Opiate Receptor from Mouse Brain

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Science  22 Feb 1974:
Vol. 183, Issue 4126, pp. 749-753
DOI: 10.1126/science.183.4126.749


A proteolipid isolated from a lipid extract of mouse brain demonstrates stereospecific binding properties for levorphanol. It is present only in neuronal tissue and most abundant in the rhombencephalon. One component saturates at a concentration corresponding to maximum pharmacologic effect in vivo. The estimated mass is 60,000 daltons per bound opiate molecule.