Penetration of Somatic Mammalian Cells by Sperm

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Science  01 Mar 1974:
Vol. 183, Issue 4127, pp. 857-859
DOI: 10.1126/science.183.4127.857


Penetration of somatic mammalian cells by spermatozoa occurred after simple admixture in culture. With sperm labeled in vivo, autoradiography revealed incorporation of DNA into nuclei of recipient cells, indicating release of DNA after entrance by sperm. This system provides a new approach to study the molecular biology of information transfer and of haploid gene expression.