Brain Hyaluronidase: Changes in Activity during Chick Development

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Science  01 Mar 1974:
Vol. 183, Issue 4127, pp. 862-864
DOI: 10.1126/science.183.4127.862


Development of embryonic chick brain is characterized by high levels of hyaluronidase activity and of hyaluronate, both of which decrease rapidly soon after the chick hatches. By analogy to other systems, it is proposed that the sequence of hyaluronate production and its enzymatic removal may have a developmental role in brain formation.