Human DNA Polymerase III (R-DNA Polymerase): Distinction from DNA Polymerase I and Reverse Transcriptase

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Science  01 Mar 1974:
Vol. 183, Issue 4127, pp. 867-869
DOI: 10.1126/science.183.4127.867


DNA polymerase III is an enzyme activity in eukaryotic cells which under certain conditions shows strong preference for polyadenylic acid as template when primed by oligodeoxythymidylate. Its first complete separation from other DNA polymerases in human lymphoblasts is reported. This enzyme is biochemically and immunologically distinct from DNA polymerase I and from viral reverse transcriptase from a primtate type C virus.