Mapping Human Autosomes: Evidence Supporting Assignment of Rhesus to the Short Arm of Chromosome No. 1

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Science  08 Mar 1974:
Vol. 183, Issue 4128, pp. 966-968
DOI: 10.1126/science.183.4128.966


Rh-negative erythrocytes were found in the blood of an Rh-positive man suffering from myelofibrosis. Nucleated hemopoietic precursors were also circulating in his blood, and these cells had an abnormal chromosome complement from which identifiable chromosome segments had been deleted. Correlation of the serological and cytogenetic findings, combined with previous data, indicates that the Rhesus blood group locus is on the distal portion of the short arm of chromosome No. 1.