Arachidonic Acid Causes Sudden Death in Rabbits

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Science  15 Mar 1974:
Vol. 183, Issue 4129, pp. 1085-1087
DOI: 10.1126/science.183.4129.1085


Injection of sodium arachidonate (1.4 milligrams per kilogram) into the marginal ear veins of rabbits caused death within 3 minutes. Histological examination showed platelet thrombi in the microvasculature of the lungs. Rabbits were protected from the lethal effects of arachidonic acid by pretreatment with aspirin. Fatty acids closely related to arachidonic acid did not cause death.