Selective Pancreatic Enzyme Secretion due to a New Peptide Called Chymodenin

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Science  15 Mar 1974:
Vol. 183, Issue 4129, pp. 1087-1089
DOI: 10.1126/science.183.4129.1087


Chymodenin, a peptide newly isolated from porcine duodenum, elicited a rapid threefold increase in secretion of chymotrypsinogen while increasing secrelion of total protein by only, about 40 percent; lipase secretion was unaffected. The pancreas appears able, under chymodenin stimulation, to rapidly alter the transport of an individual enzyme as opposed to producing en masse secretion of enzyme.