Evidence that Enzyme Polymorphisms Are Selectively Neutral, but Blood Group Polymorphisms Are Not

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Science  15 Mar 1974:
Vol. 183, Issue 4129, pp. 1091-1092
DOI: 10.1126/science.183.4129.1091


Data on enzyme polymorphism and blood group polymorphism were examined with special reference to molecular evolution, by using a statistic that depends on neither population structure nor other ecological factors. The data of the former are consistent with the hypothesis of neutral mutant and random genetic drift, whereas the latter are in accord with the hypothesis of balanced selection.