Calcium Absorption and Calcium-Binding Protein Synthesis: Solanum malacoxylon Reverses Strontium Inhibition

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Science  15 Mar 1974:
Vol. 183, Issue 4129, pp. 1092-1094
DOI: 10.1126/science.183.4129.1092


The ingestion of diets containing high concentrations of stable strontium inhibits calcium absorption and intestinal calcium-binding protein synthesis and, as shown by others, does so by inhibiting the conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol, the active form of vitamin D. The addition of the South American plant Solanum malacoxylon to strontium-containing diets counteracts the inhibitory action of dietary strontium, thereby indicating that the plant contains a factor which can mimic the action of 1,25-dihydroxycholecalciferol and representing the first such factor identified in a botanical source.