Reports

Collagen Polymorphism: Characterization of Molecules with the Chain Composition [α1(III)]3 in Human Tissues

+ See all authors and affiliations

Science  22 Mar 1974:
Vol. 183, Issue 4130, pp. 1200-1201
DOI: 10.1126/science.183.4130.1200

Abstract

Collagen moleculess with the chain comizposition [α1(III)]3, have been isolated from pepsin-solubilized collagen of dermis, aorta, and leiomlyoma of the uterus by differential salt precipitation. On denaturation, approximately 90 percent of this collagen is recovered as a γ component (300,000 daltons). Reduction and alkylation of the high-molecular-weight component yields α1(III) chains (95,000 daltons). In addition to containing cysteine, α1(III) chains exhibit several other compositional differences when compared to α1(I), α1(II), or α2 chains from human tissues.

Related Content