Visna Virus Infection of American Lambs

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Science  22 Mar 1974:
Vol. 183, Issue 4130, pp. 1202-1203
DOI: 10.1126/science.183.4130.1202


Random-bred fetal and 4-week-old American lambs, inoculated intracerebrally with visna virus, developed a persistent infection in the brain and sometimes in the lung. The pathologic changes present in these lambs were similar to the early lesions of visna in Icelandic sheep, thus providing a possible model for the study of virus-induced demyelinating disease.