Benzo[a]pyrene Metabolites: Efficient and Rapid Separation by High-Pressure Liquid Chromatography

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Science  12 Apr 1974:
Vol. 184, Issue 4133, pp. 169-171
DOI: 10.1126/science.184.4133.169


High-pressure liquid chromatography can separate eight metabolites of benzo[a] pyrene formed by rat liver microsomes. This method offers major advantages over previous techniques used for the separation of oxygenated polycyclic aromatic hydrocarbons.