Serum Induced Lymphoid Cell Mediated Cytotoxicity to Human Transitional Cell Carcinomas of the Genitourinary Tract

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Science  17 May 1974:
Vol. 184, Issue 4138, pp. 795-797
DOI: 10.1126/science.184.4138.795


In some serums of patients with transitional cell carcinoma (TCC), a factor is present which induces lymphocytes from most donors with or without TCC to become cytotoxic against TCC-derived target cells. The induced cytotoxicity was directed against target cells derived from TCC's of the renal pelvis, ureter, and urinary bladder, but not against cells derived from normal kidney, bladder, testis, or skin or from renal cell carcinoma. Cytotoxicity occurred without complement but did not occur without effector cells.