Carnosine in the Primary Olfactory Pathway

Science  24 May 1974:
Vol. 184, Issue 4139, pp. 909-911
DOI: 10.1126/science.184.4139.909


Carnosine (β-alanyl-L-histidine) is present in mouse olfactory bulbs and nasal olfactory epithelium at concentrations exceeding that previously reported for any brain region of any species. After peripheral deafferentation, carnosine concentrations in the olfactory bulbs decrease to less than 10 percent that of normal, while other amino compounds are unaffected. Carnosine appears to be highly localized to the primary olfactory pathway.