Mutagenic and Recombinogenic Activities of the Food Additive Furylfuramide in Eukaryotes

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Science  07 Jun 1974:
Vol. 184, Issue 4141, pp. 1086-1087
DOI: 10.1126/science.184.4141.1086


The mutagenic and recombinogenic activities of furylfuramide, an antimicrobial food additive, were tested in a two-component heterokaryon of Neurospora crassa and a diploid strain of Saccharomyces cerevisiae, respectively. The results show that furylfuramide is genetically active in both eukaryotic organisms; it induces mutations in Neurospora crassa and mitotic crossing over in Saccharomyces cerevisiae.