Lateral Phase Separation of Lipids in Plasma Membranes: Effect of Temperature on the Mobility of Membrane Antigens

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Science  14 Jun 1974:
Vol. 184, Issue 4142, pp. 1183-1185
DOI: 10.1126/science.184.4142.1183


Cooling populations of newly formed mouse human heterokaryons has effects on the intermixing of mouse and human surface antigens which indicate the occurrence of phase separations in membrane lipids. Antigen mixing, previously shown to be due to diffusion in the plane of the membrane, is retarded when cells are cooled from 37° to 21°C, but is then speeded by further cooling to 15°C. This result is in accord with observations on phase separations of lipids in artificial and bacterial membranes.