Growth Hormone Responses to Melatonin in Man

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Science  28 Jun 1974:
Vol. 184, Issue 4144, pp. 1373
DOI: 10.1126/science.184.4144.1373


Oral administration of 1 gram of melatonin caused rapid and significant elevations of serum human growth hormone in eight out of nine normal male subjects. The mean (± standard error of the mean) of the peak response by growth hormone was 22.9 ± 4.6 microunits per milliliter. The increased secretion of growth hormone may be due to interaction of melatonin with hypothalamic serotoninergic receptors.