Control of Experimental Diabetes Mellitus in Rats by Transplantation of Fetal Pancreases

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Science  28 Jun 1974:
Vol. 184, Issue 4144, pp. 1377-1379
DOI: 10.1126/science.184.4144.1377


Experimental diabetes mellitus in young adult Lewis rats was successfully treated by transplantation of fetal pancreases from syngeneic fetuses. Complete or partial control lasting up to 165 days was achieved in 64 percent of recipients by using two to three pancreases of fetal age (15 to 18½ days) placed under each kidney capsule. Islets of Langerhans without exocrine elements were present in the transplants.