Malignant Melanoma: Specific Immunity Induced by Bacillus Calmette-Guérin in BALB/c Mice

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Science  05 Jul 1974:
Vol. 185, Issue 4145, pp. 68-69
DOI: 10.1126/science.185.4145.68


Previous treatment of BALB/c mice with bacillus Calmette-Guérin (BCG) will significantly protect them against intramuscular challenge of S-91 melanoma but not against a mammary carcinoma or a methylcholanthrene-induced sarcoma. Lymphocyte-mediated cytotoxicity studies correlate with in vivo data in showing that BCG-immune lymphocytes are specifically cytotoxic to S-91 melanoma target cells but not to the carcinoma or sarcoma target cells.