Thyrotropin-Releasing Hormone: Regional Distribution in Rat Brain

See allHide authors and affiliations

Science  19 Jul 1974:
Vol. 185, Issue 4147, pp. 265-267
DOI: 10.1126/science.185.4147.265


A sensitive and specific radioimmnunoassay has been used to measure the distribution of thyrotropin-releasing hormone (TRH) in rat brain. All areas of brain tested, except cerebellum, contained readily measurable amounts of TRH. The hypothalamus contained only 31.2 percent of the total brain content of TRH. These results support recent suggestions of central actions for TRH in addition to its hypophysiotropic functions.