Extracellular Acidosis Protects Ehrlich Ascites Tumor Cells and Rat Renal Cortex against Anoxic Injury

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Science  19 Jul 1974:
Vol. 185, Issue 4147, pp. 277-278
DOI: 10.1126/science.185.4147.277


The present study indicates that extracellular acidosis protects Ehrlich ascites tumor cells and rat kidney cortex cells against injury from anoxia. Parameters measured included cell potassium, adenosine 5'-triphosphate, and uptake of vital dyes. Cells survived longer at a pH of 5.6 to 6.5 than at a pH of 7.4; pH 7.9 was most detrimental. These findings indicate that production of protons by anoxic cells may be a protective feedback mechanism.