Cation Dependence of High-Affinity Angiotensin II Binding to Adrenal Cortex Receptors

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Science  19 Jul 1974:
Vol. 185, Issue 4147, pp. 281-283
DOI: 10.1126/science.185.4147.281


The specific binding of monoiodinated angiotensin II by particulate receptors from the bovine adrenal cortex is enhanced by addition of sodium and potassium ions, but not other cations. In the presence of 140 millimolar sodium, increased uptake of angiotensin II by adrenal receptors is associated with the appearance of high-affinity binding sites with an association constant of 2 x 109 liters per mole.